File Name: File Size: File Type: Chemical_Carcinogens_1.ppt: 101376: PPT File index.asp: 33067: ASP File • It is listed in either Group 2A (“limited evidence of carcinogenicity” from human studies) or 2B (“sufficient evidence of carcinogenicity” from animal studies) by IARC or under the category “reasonably anticipated to be carcinogens by NTP. Neoplasia V Carcinogenesis - . Chemical carcinogenesis in mouse or rat livers and other organs is known to be prevented or modulated by BHA, bisethylxanthogen, and other antioxidants. • Fume hoods--full open face velocity of 8o to 100 l.f.p.m.. combined with a dry ice capture test. • Employees must be trained in the content of the SOP. • Carcinogens are chronic toxins. A seminal breakthrough was Yamagiwa's production of skin tumors in rabbits by the direct application of coal tar in 1915, which led to the isolation, identification, synthesis, and biological testing of polycyclic aromatic hydrocarbons (PAHs) as chemical carcinogens, including dibenz[a,h]anthracene and … Chemical Carcinogens Providence Va Medical Center PPT Presentation Summary : CHEMICAL CARCINOGENS What is a carcinogen? overview of carcinogenic agents. • No shorts or open toed shoes. Chemical Carcinogens Etiology of Cancer Chemical carcinogens. 6. Many thousands of additional compounds are “suspect” carcinogens. Training needed. : Vinyl chloride Carbon tetrachloride Chloroform Hexachlorobenzene Trichloroethylene • Hydrazines: Hydrazine (and salts) 1,2-Dimethylhydrazine • N-Nitroso compounds: N-Nitrosodimethylamine • Aromatic Amines: Benzidine Aniline o-Anisidine o-Toluidine • Aromatic hydrocarbons: Benzene Benz[a]anthracene Benzo[a]pyrene, Classes of carcinogens (cont.) dec 3, 2008. carcinogens : there exists a “measurable” risk from any exposure, eg 4.1 x 10 -6, Chemical Changes - Presented by: bailey newbill. If you continue browsing the site, you agree to the use of cookies on this website. are there differences in the mechanisms of carcinogenesis associated with, Types of Toxicants - . Chemical Carcinogens 7. Most carcinogens, singly or in combination, produce • Viral oncogenesis. • Experiments with animals are based on the premise that chemicals that produce cancer in animals will have similar effects on human cells. Do not make more stock solutions than are required. Now customize the name of a clipboard to store your clips. • Separated by shelving system or secondary containment. &Carcinogenic Agents. See our Privacy Policy and User Agreement for details. what is a chemical change?. • Results of monitoring must be supplied to the employee. 8. • Wash hands and any exposed skin if potentially contaminated--face, neck, forearms, etc. • Protective clothing--lab coats, aprons, Tyvek garments. • Remove lab coat or other potentially contaminated protective clothing before leaving the work area. Shigeki Tsuchida, in Encyclopedia of Cancer (Second Edition), 2002. What is a carcinogen?. human carcinogens. a carcinogen is any substance, radionuclide, Carcinogenesis - . chemical reactions and chemical. Carcinogens pp 1. What is a chemical carcinogen? • Special solutions or solvents on hand if required for decontamination of skin, eyes. Personal hygiene • No smoking, eating, drinking or application of cosmetics is permitted in areas where carcinogens are in use (or in any lab area!). styrene regulatory update styrene california workshop october 28, Risk Assessment II - . rachelle heller. Carcinogens are agents that can cause cancer. © 2020 SlideServe | Powered By DigitalOfficePro, - - - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - - -. How do I reduce my inventory and level of waste generation? introduction. chapter 10. chemical reactions and equations: basic concepts. • Ingestion. ... Tar, which formed up to 1/3 of the chemical of soot, was the chief suspect. View Assignment - Chemical_Carcinogens_1.ppt from OMI 112 at Carville Job Corps Academy. • Only authorized persons trained in the use of the carcinogens present may use these areas when such materials are in use. Etiology of Cancer • Chemical carcinogens. • Any substance that is regulated by OSHA as a carcinogen. CHEMICAL CARCINOGENS. How do I reduce my exposure to carcinogens? Personnel monitoring with sample pumps or badges. The … • Kennaway and Cook–First pure chemical carcinogen, dibenz(a,h) anthracene, 1930. • Any substance that is capable of causing cancer. chemical changes. Viral oncogenesis. • Cigarette smoking (co-carcinogen) • Alcohol consumption (co-carcinogen) • Diet--high fat consumption, natural antioxidants • Geographic location--industrial areas, UV light • Therapeutic drugs--some are known carcinogens • Inherited conditions, How do I reduce my exposure to carcinogens? carcinogens. What organs to carcinogens attack? Engineering controls--exhaust ventilation and equipment • General room ventilation--10 or more changes of air per hour. • Training--all employees using carcinogens must be trained in the recognition of the physical and health hazards associated with the carcinogens they are working with, methods to detect the presence or release of a carcinogen and ways to protect themselves from exposure to the carcinogens with which they are working. • Mutagens are chronic toxins • Teratogens act during pregnancy to cause adverse effects on the embryo or fetus including malformations, retarded growth and post- natal deficiencies. What is an OSHA “select” carcinogen? Ionizing Radiation • Ionizing radiation includes: X-rays, gamma rays, as well as particulate radiation; alpha, beta, protons, neutrons and primary cosmic radiation. products. • Miller and Miller–Ultimate carcinogenic metabolites are electrophiles adducting DNA, 1967. Administrative controls • Material Safety Data Sheets and other information. How do I reduce my inventory and level of waste generation. • Records of exposures,. Radiation carcinogenesis. Defects in DNA repair capacity are associated with a high risk of cancer. • Many are commonly used in laboratory operations, shops and art studios. Get powerful tools for managing your contents. INTRODUCTION Public opinion considers cancer to be an increasingly threatening disease, affecting people of all ages. • With very few exceptions (dilute formaldehyde solutions) carcinogens may never be discharged to the sanitary sewer. Like fibers, particulate matter is most often inhaled, but can also be ingeste… Engineering controls--exhaust ventilation and equipment. chemical reactions. • Fire extinguisher at hand as required. • “DANGER--Contains ___________ CANCER HAZARD”, Storage of containers • Carcinogens must be stored separately from other materials. section 3.2. objectives. topic 8. recognizing chemical, Tobacco Use - . Carcinogenesis, also called oncogenesis or tumorigenesis, is the formation of a cancer, whereby normal cells are transformed into cancer cells.The process is characterized by changes at the cellular, genetic, and epigenetic levels and abnormal cell division.Cell division is a physiological process that occurs in almost all tissues and under a variety of circumstances. Regulation of gene regulation in Eukaryotes, No public clipboards found for this slide, Student at All India Institute of Medical Sciences. environmental & occupational carcinogens. organic compounds: Formaldehyde Acetaldehyde 1,4-DioxaneEthyl carbamate 2-Nitropropane Styrene Thiourea Thioacetamide • Misc. Recently much work has been done to express carcinogenic potency quantitatively as the daily dose that will result in cancer in 50% of test animals in long-term experiments (18 or 24 months, most of the life-span of a rat or mouse). A Right-to-Know (RTK) style label must be on any container of material that is repackaged or made into a solution more than 0.1%. list 6 types of tobacco products. Key words: cancer stages,carcinogenesis evaluation, chemical carcinogens, chemical carcinogenesis. Hence, polymorphisms of endogenous enzymes such as … Swallowing of a carcinogen. It may be a substance in the air, a product you use, or a chemical in foods and drinks. • Reproductive toxins can affect both men and women. ABSORPTION AND METABOLISM OF CHEMICAL CARCINOGENS. Their common feature is that their ultimate forms are electrophilic reactants; in most cases, these reactants arise through metabolism in vivo. How is chemical carcinogenicity determined? Presentation Summary : CHEMICAL CARCINOGENS What is a carcinogen? Cells constantly deal with the formation of DNA adducts from either endogenous or exogenous influences (Greenfield et al., 1984; Hoeijmakers, 2009; Phillips et al., 2000), including DNA damage that occurs secondary to radiation. by: pedicatric pandemic. chemical reactions involve a chemical change. • Secondary containment means placing chemical containers in an outer container to prevent the release of a chemical in the event that its container breaks or ruptures. • Misc. If you continue browsing the site, you agree to the use of cookies on this website. Etiology Of Cancer Several examples for typical genotoxic carcinogens will be given. Getting cancer from a chemical depends on the following: •The kind of chemical you were exposed to, •How much of the chemical you were in contact with, •How long the contact lasted, •How often you were exposed, Carcinogen, any of a number of agents that can cause cancer in humans. Decontamination and emergency procedures • Safety shower and eyewash station nearby. • No benchtop work in a laboratory setting. describing chemical reactions indications of a chemical reaction. Any substance that is capable of causing cancer. Housekeeping and maintenance • Keep all work surfaces and equipment clean. what is a carcinogens. • OSHA standards for personal protective equipment supersede other OSHA standards. 21. unit 5: diversity of matter. In early studies, it was observed that a long latent period could elapse from exposure to carcinogens to the development of cancer. Regulated areas • Establish regulated or designated areas for the use of carcinogens. • All areas where carcinogens may be used, present or stored should have prominently displayed warning signs or labels both in the areas and access to them.. They can be divided into three major categories: chemical carcinogens (including those from biological sources), physical carcinogens, and oncogenic (cancer-causing) viruses. • Any discrete chemical compound which has been shown to cause cancer in human or animal studies. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. chemical equations. 1. Chemical carcinogenesis Lorne J. Hofseth, PhD Ainsley Weston, PhD Curtis C. Harris, MD Overview Human exposure to chemical carcinogens can result in cancer. 8. • Inhalation. Training required. • Eye protection--safety glasses, splash goggles, face shields. • Waste bottles must be properly labeled, tightly capped at all times (except when adding or removing waste) and they must have secondary containment. presentation to cancer, Descriptive vs.- Quantitative Risk Assessment of Genotoxic Carcinogens London, April 2, 2009 - Dealing with genotoxic, Writing Chemical Equations - . • Spill mixtures and cleanup materials for spills on hand. chemical carcinogens physical agents, Chemical Reactions - . Chloroform, DDT, formaldehyde, and polychlorinated biphenyls (PCBs) are examples of possible human carcinogens. • Substitute less hazardous materials for carcinogens whenever possible; toluene instead of benzene. 4. The known chemical carcinogens include a wide range of structures. Environmental tobacco smokeEpichlorohydrinEthyl acrylateEthylene dibromideEhtylene dichlorideEthylene oxideEthyleneimineEthylene thioureaFormaldehydeGallium arsenideGasoline Cancer is the abnormal or uncontrolled growth of new cells in any part of the body, characterized by cells that tend to invade surrounding tissue and metastasize to new body sites. • Written exposure control plans, if required. 27 slides: Chemical Carcinogens Carcinogens are chronic toxins. Any substance that is capable of causing cancer.Any substance that is capable of causing cancer. • Mutagens cause damage to chromo-somes by introducing changes to DNA. • Asbestos • Certain chemicals • Coal tars and coke oven emissions • Hardwood sawdust (certain species) • Ionizing radiation • Natural products (progesterone, safrole) • Tobacco smoke • Ultraviolet radiation. Carcinogenesis by chemicals is a multistage process. Cancer is the abnormal or uncontrolled growth of new cells in any Following exposure, chemical carcinogens may be absorbed in a number of ways (oral, inhalator, cutaneous, and injection) and distributed across several tissues (Connoly et al. Chemical Carcinogens Providence Va Medical Center PPT. Chemical Carcinogens 1 - Free download as Powerpoint Presentation (.ppt), PDF File (.pdf), Text File (.txt) or view presentation slides online. How is chemical carcinogenicity determined? (A specified dose range is given. • Carcinogens may never be disposed of in the ordinary trash. • Dose--amount and length of exposure. These induce GSTs and other drug-metabolizing enzymes, and their induction of GSTs closely correlates with their tumor inhibitory activity. • Detoxify carcinogens as part of your research protocols. Particulate matter includes a variety of different compounds that are naturally present as tiny particles. The role of metabolic activation in carcinogenesis and the importance of DNA damage and mutation have led to additional avenues of research regarding mechanisms of carcinogenesis and influences on the carcinogenic process. tiina santonen 4.11.03 paide. • Local ventilation--exhaust (sometimes supply) at the point of use of a chemical. Related Chemical Safety Training Courses Chemical Protection Clothing Chemical Hygiene and Engineering Chemical Spill Chemical Safety Chemical Handling Chemical Carcinogens by Estonian OH&S Number of Slides:22 Created By:Estonian OH&S This training presentation was created by Estonian OH&S. • Written emergency response plan. Any substance that is capable of causing cancer. Ionizing Radiation Ionizing radiation includes: X-rays, gamma rays, as well as particulate radiation; alpha, beta, protons, neutrons and primary cosmic radiation. chemicals or types of radiation, Chemical Reactions - . In 1941, Rous and Kidd painted the skin of rabbits and found that if this painting were interrupted, tumors would disappear only to reappear if the application of tar was re-estab… They cause damage after repeated or long-duration exposure. Required whenever there is a spill or other emergency. Chemical carcinogens are not normally reactive by themselves, but need metabolic activation to form highly reactive, electrophilic species (ultimate carcinogens), interacting with nucleophilic sites in the cell, especially in DNA. • Area monitoring may be required in some cases. The first stage, initiation, occurs rapidly and appears to be irreversible. Carcinogens in the Environment - . a chemical change is a, 3 ways of representing the reaction of H 2 with O 2 to form H 2 O - Reactants. Formaldehyde is easily detoxified by NH4OH, for example. • Storage areas must be labeled “Danger--Carcinogens Stored Here.”. chapter 21: chemical reactions. ... Ionizing radiation Natural products (progesterone, safrole) ... – A free PowerPoint PPT presentation (displayed as a Flash slide show) on PowerShow.com - id: 783f26-NjRkM • All contaminated floor sweepings, debris (paper towels, Kimwipes, plasticware), discarded filters from respirators or vacuums must be bagged, properly labeled and sent out for incineration. Lab coats need to be cleaned regularly; special washing instructions may be needed. • Animal studies directly induce cancer in test animals using a large sample of animals, usually of two or more species with varying dose and time parameters. Most chemical carcinogens are mutagens 2. Factors governing the outcome include type of exposure, amount of exposure, time of exposure, and genetic makeup of the host (i.e., humans).… Chapter 21: Chemical Reactions - 21. table of contents. See our User Agreement and Privacy Policy. • Hueper–2-naphthylamine as bladder carcinogen in dogs, latency in carcinogenesis, 1937. Examination by a physician, blood tests, etc. CTD: a resource for predicting chemical-gene-disease networks - . These particles are, in some cases, mined for human use. This may be done by EH&S staff. Designed to reduce exposures below the permissible exposure limit (PEL). Use an “ALARA” policy. What materials are carcinogens? Chemical Carcinogens – Cancer 16 By The Fasting Method. After cardiovascular diseases, it is the second cause of death amongst the global population (Huff 1994, Weisburger • Locations where entry and exit or use of an area is restricted to the use of carcinogens. husni maqboul, m.d. • Any “incidental” spill may be cleaned up by the lab staff; larger spills may require a emergency response (5-1111). Thorium dioxide Beryllium and compounds Cadmium and compounds Lead and compounds Nickel and compounds Selenium sulfide. 9. III.C Prevention of Carcinogenesis. • Biosafety cabinet--used for anticancer drugs, viruses. What dictates this outcome is relatively predictable but highly variable. carolyn mattingly north carolina state university. • Plan the use of carcinogens carefully. identify the drug that makes tobacco addictive. Title: Chemical Carcinogenesis Author: iir Last modified by: Lenovo User Created Date: 2/21/2000 1:27:05 PM Document presentation format: On-screen Show (4:3) – A free PowerPoint PPT presentation (displayed as a Flash slide show) on PowerShow.com - id: 749e8f-N2NjZ They may have not immediate apparent harmful effects, with cancer developing only after a long latency period. A specific chromosomal abnormality can be associated with human leukemia. Clipping is a handy way to collect important slides you want to go back to later. • Respirator may be needed for spill cleanup. “Elephant trunk” or slot hood. : Arsenic and compounds Chromium and comp. • Regulated areas are usually under negative pressure (fume hood) to contain carcinogens in the hood or room. How do carcinogens enter the body? What are reproductive toxins? The Styrene Information & Research Center - . inorganic comp. ), Which classes of chemicals tend to be carcinogens? Chemical carcinogens may bind to DNA. Generally, workplace exposures are considered to be at higher levels than for public exposures. • Cancer is the abnormal or uncontrolled growth of new cells in any part of the body, characterized by cells that tend to invade surrounding tissue and metastasize to new body sites. (Required in Lab Standard.) • Mutagens have adverse effects on fertility and general reproductive performance. chemical change = chemical reaction a chemical equation is a, 2.6 Chemical Equations - A chemical equation is the symbolic representation of a chemical reaction in terms of chemical. safety file Any substance that is capable of causing cancer. Place no longer needed materials in a recycling program or dispose of as waste. • It is listed under the category “know to be carcinogens” in the Annual Report on Carcinogens published by the National Toxicology Program (NTP). at the end of this lesson, you will be able to: translate, Chemical Reactions - . • Desiccators, plastic boxes, bottle-in-can are acceptable secondary containment. They cause damage after repeated or long-duration exposure. Many solvents and other chemicals go directly through the skin. of the work of cco/octrf. monitoring, and medical exams must be kept for 30 years. • Limitations on the duration of exposure. Create stunning presentation online in just 3 steps. ...… what we know and don’t know about the relationships between exposure to certain. How do I dispose of waste carcinogens? • Dry wastes must be incinerated or shipped out as regulated medical waste (“chemotheraputic agents”). • Carcinogen glove box or environmental chamber. GGS Medical College/Baba Farid Univ.of Health Sciences. What is a carcinogen?What is a carcinogen? 1. Contaminated disposable clothing should be treated as hazardous waste, Labeling of containers • All containers of chemical carcinogens need to have a warning label affixed to them. Check “Poison” on the waste label. 7. No mouth pipetting! Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. • Specialized training may be required for specific carcinogens. Which classes of chemicals tend to be carcinogens? classification based on particular effects on health. • Purchase carcinogens in the smallest possible quantities. • Medical monitoring may be required if it is anticipated that PELs may be exceeded. it’s a process in which one or more reactants are, Chemical Reactions - . Chemical carcinogens have highly reactive electrophile groups that directly damage DNA, leading to mutations and eventually cancer. 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